Clinical trials Brief October 30, 2026, 12:01 AM ET

PROSpect trial finds no difference in ventilator-free days with prone positioning or HFOV

The PROSpect phase 3 trial, enrolling 424 of 600 planned patients, found no significant difference in ventilator-free days between prone and supine positioning (median 17·9 vs 17·4 days) or between HFOV and conventional ventilation (17·3 vs 18·0 days). The authors reported more frequent airway obstruction and immobility-related pressure injuries with prone positioning and more haemodynamic instability with HFOV, concluding that routine use of these strategies is not recommended.

Primary source

PubMed record of a Phase III journal article, October 29, 2026

Prone positioning and high-frequency oscillatory ventilation in early paediatric acute respiratory distress syndrome (PROSpect): an international, two-by-two factorial, response-adaptive, phase 3, randomised controlled trial.

Read the source: Prone positioning and high-frequency oscillatory ventilation in early paediatric acute respiratory distress syndrome (PROSpect): an international, two-by-two factorial, response-adaptive, phase 3, randomised controlled trial. pubmed.ncbi.nlm.nih.gov

By The Priority Review desk. Machine-summarized from the source above; not independently reported. How we use automation