PROSpect
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PROSpect trial finds no difference in ventilator-free days with prone positioning or HFOV
The PROSpect phase 3 trial, enrolling 424 of 600 planned patients, found no significant difference in ventilator-free days between prone and supine positioning (median 17·9 vs 17·4 days) or between HFOV and conventional ventilation (17·3 vs 18·0 days). The authors reported more frequent airway obstruction and immobility-related pressure injuries with prone positioning and more haemodynamic instability with HFOV, concluding that routine use of these strategies is not recommended.